Synthesis & size selection
Develop AuNP preparations and select particle dimensions around colour, stability and assay requirements.
AuNP synthesis, surfaces & bioconjugation
Gold nanoparticles, developed around the assay.
Radetec develops colloidal gold nanoparticles and AuNP conjugates for lateral flow, immunoassay and other bioanalytical research. We connect particle size, surface chemistry and biomolecule loading to the signal and stability the final workflow requires.
Why gold nanoparticles?
A practical optical label with versatile surface chemistry.
Gold nanoparticles produce a strong visible colour and are widely used as labels in lateral flow tests. Useful performance, however, depends on more than the particle itself: size distribution, colloidal stability, surface coverage, binder activity, conjugate release and sample matrix all influence the final signal.
We develop the nanoparticle and conjugation conditions with the downstream assay in view, then evaluate the conjugate under relevant buffer and membrane conditions.
Development scope
From colloid to assay-ready conjugate.
Projects can begin with custom synthesis, an existing particle, an antibody pair or a lateral flow assay that needs a more reliable label.
Surface optimisation
Evaluate pH, buffers, coatings and blocking conditions that influence colloidal behaviour and non-specific interactions.
Bioconjugation
Optimise passive adsorption or suitable covalent strategies for antibodies and other recognition molecules.
Assay integration
Assess conjugate release, test-line signal, background and compatibility with the intended sample workflow.
Technical perspective
Gold nanoparticle conjugation is application-specific.
Particle concentration and antibody loading are useful starting variables, but they do not define a successful conjugate on their own. We assess retained binding activity, aggregation risk, storage behaviour and performance in the final detection format.
Can you synthesise custom gold nanoparticles?
Yes. We can scope gold nanoparticle synthesis and size selection around the intended optical signal, surface chemistry and assay workflow.
Can you conjugate our antibody?
Yes. A project can evaluate antibody loading, coupling conditions, blocking and retained recognition activity before integration into the assay.
Do you support lateral flow development?
Yes. Gold nanoparticle development can be combined with membrane, buffer, capture-line and sample-flow optimisation through our lateral flow assay development service.
Can you troubleshoot an existing conjugate?
Yes. We can investigate aggregation, weak signal, high background, poor release and batch inconsistency against an agreed baseline.
Start with the application
What does your gold label need to do?
Share your target, binder, sample matrix, preferred particle size and intended assay. We can define a focused synthesis, conjugation or assay-integration study.
Discuss your AuNP project