Radetec / Contract R&D / Melbourne

Gold Nanoparticle & Quantum Dot Bioconjugation

Connect nanoparticle design and bioconjugation to the signal, stability and workflow your assay needs.

Discuss your project

Development scope

From the first question
to the next milestone.

01Label selection

Select gold or fluorescent quantum-dot labels based on assay format, readout and practical handling requirements.

02Surface chemistry

Evaluate surface functionalisation, coatings and colloidal behaviour in the intended assay environment.

03Bioconjugation

Develop coupling conditions for suitable recognition reagents and evaluate binding activity and non-specific interactions.

04Assay integration

Assess conjugate performance in the target workflow, including signal, background and compatibility with storage conditions.

QD conjugation example

From nanoparticle surface
to biological binding.

These Radetec microscopy images compare Qdot-azide particles with a Qdot–EGFR nanobody conjugate and show the conjugate interacting with EGFR-GFP expressing cells.

Negative-stain TEM image of Qdot-azide particles with a 50 nanometre scale bar — **Qdot-azide only.** Negative-stain TEM. Scale bar: 50 nm.

Negative-stain TEM image of Qdot-EGFR nanobody conjugates with a 50 nanometre scale bar — **Qdot–EGFR nanobody conjugate.** The conjugated particles show a thicker protein layer. Scale bar: 50 nm.

Red fluorescence image of Qdot-EGFR nanobody conjugate in cells — Qdot–EGFR nanobody conjugate

Green fluorescence image of EGFR-GFP expressing cells — EGFR-GFP expressing cells

Merged fluorescence image showing Qdot-EGFR nanobody conjugate with EGFR-GFP expressing cells — Merge: conjugate binding and internalisation

Microscopy images supplied by Radetec. Fluorescence scale bars: 10 µm.

Technical perspective

What matters in development

The particle surface and coupling method can influence binding activity, colloidal stability and non-specific signal. We develop nanoparticle labels in the context of the intended assay, including antibody conjugation and downstream readout.

Common project questions

Do you work with gold and fluorescent labels?

Yes. Projects may evaluate gold nanoparticles or fluorescent quantum dots according to the required readout and assay workflow.

Can you evaluate a conjugate in our assay?

Yes. Assay integration can include signal, background and compatibility checks under the conditions agreed for the project.

Explore our CdSe/ZnS, InP/ZnS and CuInS₂/ZnS quantum dot systems and QD conjugation approach.

Explore other nanomaterials

Let's find your starting point

Have a project in mind?

Share your assay requirements or formulation goals and current stage. We'll discuss how to structure the next step.

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